20MG TABLETS 14 IPRAALOX

IPRAALOX 20MG COMPRIMES 14 View larger

3400921798135

Sanofi Aventis Sanofi Aventis

The IPRAALOX 20 mg is a medicine indicated for the current term treatment of symptoms of gastroesophageal reflux in adults.

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For warnings, the precautions and cons-indications, please see the instructions.

Description

Indications
The IPRAALOX 20 mg is a drug indicated for the treatment in the short term symptoms of gastroesophageal reflux in adults.

Dosage and route of administration

Usual dose: 1 tablet per day. Stop once the symptoms disappeared, not to exceed 4 weeks of treatment without medical advice. Orally.

Composition
PANTOPRAZOLE sodium sesquihydrate. EXCIPIENTS: MALTITOL (E965); CROSPOVIDONE TYPE B; carmellose sodium, Sodium Carbonate Anhydrous, CALCIUM STEARATE; POLYVINYL ALCOHOL, TALC, TITANIUM DIOXIDE (E171); MACROGOL 3350, SOY LECITHIN, YELLOW IRON OXIDE, sodium lauryl sulfate , Polysorbate 80, triethyl citrate; QSP 1 TABLET

Excipients known
SOY LECITHIN
MALTITOL
Cons-indications and warnings
Hypersensitivity to any component. Should not be administered with atazanavir.
Not recommended in patients with a history of gastric ulcers, gastrointestinal surgery, liver failure or liver disease, dyspepsia patient to be an endoscopy or urea breath test. Should not be used as a preventive measure.

Packaging
Blister 14 tablets

Warnings on drugs

Warning, the drug is not a product like any other. Read the package leaflet before ordering. Do not leave medicines out of reach of children. If symptoms persist, seek the advice of your doctor or pharmacist. Attention to incompatibilities on products in your.

Tell your pharmacist online treatments underway to identify possible incompatibilities. The checkout form contains a custom message field provided for this purpose.

Click here to find record of the drug at the site of the National Security Agency of Medicines and Health Products.

Pharmacovigilance : Report or a related adverse event (s) (s) (s) the use of a drug

VIDAL OF THE FAMILY

IPRAALOX

Gastric antisecretory

pantoprazole

. Presentations . Composition . Indications . Warning . Drug Interactions . Pregnancy and breastfeeding . Directions for use and dosage . Advice . Undesirable effects . Lexicon

PRESENTATIONS (summary)

IPRAALOX 20 mg: gastroresistant tablet (yellow); box of 7.
-

IPRAALOX 20 mg: gastroresistant tablet (yellow); box of 14.
-

Laboratory Sanofi-Aventis France

COMPOSITION (summary)
p cp
pantoprazole 20 mg
Soy lecithin +
maltitol +

INDICATIONS (summary)
This drug belongs to the family of proton pump inhibitors (PPIs). It reduces the secretion of gastric acids and thus makes it possible to combat the pains due to the reflux of the acid content of the stomach in the esophagus. It acts prolonged but delayed: the decline in the acidity of the stomach requires a delay of a few days.
It is used in the treatment of short-term symptoms of gastroesophageal reflux (heartburn, regurgitation ...).
WARNING (Contents)
The effect of proton pump inhibitors is not immediate. 2 or 3 days of treatment may be required to observe a decrease in pain. This medication may not be appropriate if heartburn is too much (less than twice a week). Consult your pharmacist.
It is best to consult a doctor in the following situations:
  • digestive disorders appearing for the first time, or if disorders have changed recently;
  • disorders associated with weight loss;
  • difficulty swallowing or persistent abdominal discomfort.
Precautions are necessary in patients with hepatic impairment .
People with gastroesophageal reflux should avoid using drugs containing aspirin or NSAIDs that increase stomach acid. Paracetamol, on the other hand, is safe to treat pain or fever.
Driver: This medicine may cause dizziness and difficulty in seeing.
DRUG INTERACTIONS (summary)
This medicinal product must not be combined with medicinal products containing atazanavir ( REYATAZ ).
PREGNANCY AND BREAST-FEEDING (summary)
Pregnancy :
No adverse effects to the unborn child have been established with this medication. Nevertheless, as a precaution, its use during pregnancy is reserved for situations for which there is no therapeutic alternative.

Breastfeeding:
The data currently available do not indicate whether this drug passes into breast milk: it is not recommended for use during breast-feeding.
DIRECTIONS FOR USE AND DOSAGE (summary)
This medication is taken before a meal, preferably at the same time each day. It should be swallowed with a glass of water, without being crushed or crushed.

Usual dosage:

  • Adult over 18 years: 1 tablet per day.
Treatment should not exceed 4 weeks without medical advice. If symptoms persist after 2 weeks of treatment or recurrence at discontinuation of treatment, testing may be required.

TIPS (summary)
Drug therapy for gastroesophageal reflux can only be conceived when the following simple measures have not been able to eliminate the symptoms:
  • do not lie down within two hours after a meal;
  • do not lean forward (bend knees to pick up objects);
  • do not wear clothes that compress the abdomen (sheath ...);
  • raise the head of the bed 5 to 10 cm by placing wedges under the feet or a thick pillow under the mattress;
  • avoid soft drinks, prefer easy-to-digest foods.
These tips are intended to prevent the acid content of the stomach from flowing back into the esophagus during digestion.
If you are a smoker, continuing smoking is an important barrier to treatment; nicotine increases gastric acidity and reduces the effectiveness of the muscle that closes the junction between the esophagus and the stomach.
POSSIBLE ADVERSE EFFECTS (summary)
The most frequent (in about 1% of patients): headache, diarrhea .
Uncommon: dizziness , constipation, nausea, vomiting, dry mouth, abdominal discomfort, itching, rash , tiredness, discomfort, sleep problems.
Rarely: joint or muscle pain, blurred vision, increased transaminases or triglycerides , depression.
Very rare: allergic reaction (urticaria, angioedema , anaphylactic shock ), edema, decreased white blood cells or platelets in the blood, hallucinations, confusion of ideas, hepatitis .


GLOSSARY (summary)


NSAIDs
Abbreviation for non-steroidal anti-inflammatory drug. Family of anti-inflammatory drugs that are not derived from cortisone (steroids), and the best known of which is aspirin.


anaphylactic shock
Shock of allergic origin manifested by a sudden drop in blood pressure, due to extreme dilation of the blood vessels. It occurs after contact with an allergenic substance (food, insect bites, injection or drug absorption).


diarrhea
The strict medical sense of diarrhea is "emission of stools too frequent and too abundant". In fact, common sense equates diarrhea with the notion of fluid and frequent stools. Normally, stools are pasty, but the emission of liquid or barely formed stools, without pain or particular associated disorder, is not pathological. Diarrhea can occur when liquid stool emissions are repeated during the day and the needs are overwhelming or painful.
Many medicines can accelerate intestinal transit and make the stools more liquid, without this undesirable effect being of real concern.
Antibiotics can alter the digestive flora, essential for digestion, and cause more or less troublesome but benign diarrhea. The effect appears immediately or after a few days of treatment. A severe and exceptional form of diarrhea, pseudomembranous colitis, can be observed after antibiotic treatment; this condition results in the emission of mucus and false membranes (resembling skin flaps) associated with abdominal pain; constipation may replace the initial diarrhea. Pseudomembranous colitis can occur several days after discontinuation of antibiotic treatment and requires urgent medical advice.


skin rash
Appearance of pimples or plaques on the skin. These lesions can be due to a food, a drug, and translate an allergy or a toxic effect. Many viruses can also cause pimple eruptions: rubella, roseola and measles are the most common.


enteric
Qualifies certain tablets or capsules in which the active substance is protected from the acidity of the stomach.


white blood cells
Cell present in the blood. There are several types: neutrophils, which increase during infections; the eosinophilic polynuclear cells, which are high in allergic persons or in cases of parasitosis; basophilic polynuclear cells; lymphocytes and monocytes, the number of which increases in the event of viral infection or of bone marrow disease.


hepatitis
Inflammation of the liver. It may be due to a drug, a virus, alcohol or some other cause.
Viral hepatitis usually heals without treatment. Unlike hepatitis A and E almost always benign, hepatitis B and C can become chronic: the virus persists in the patient's body which remains contagious but does not necessarily suffer from liver problems. Chronic hepatitis is said to be active when the virus continues to destroy liver cells, resulting in increased transaminases in the blood.


Hepatic insufficiency
Inability of the liver to perform its function, which is essentially the elimination of some waste, but also the synthesis of many biological substances essential to the body: albumin, cholesterol and coagulation factors (vitamin K, etc.).


platelets
Small cells in the blood: they participate in the formation of clots.


angioedema
Allergy edema usually affects the face. Quincke edema results in a sometimes spectacular swelling. Eyelids are often the first to be affected. In rare cases where edema affects the throat, respiratory problems may occur and urgent treatment is required.


allergic reaction
Reaction due to hypersensitivity of the organism to a drug. Allergic reactions can take a wide variety of aspects: urticaria, angioedema, eczema, eruption of pimples resembling measles, etc. Anaphylactic shock is a generalized allergic reaction that causes discomfort due to a sudden drop in blood pressure.


gastroesophageal reflux
Raising the gastric juice in the esophagus and in the back of the throat, favored by the extended position after meals, by leaning forward, by wearing clothes that compress the abdomen. This reflux is sometimes due to a hiatal hernia.


symptoms
Trouble felt by a person with an illness. The same symptom can translate different diseases and the same disease does not necessarily give the same symptoms in all the patients.


transaminases
Enzymes dosed in the blood, which rate rises during some hepatitis. They are included in blood tests as SGOT and SGPT or ASAT and ALAT.


triglycerides
Fats circulating in the blood. They come mainly from the assimilation of fatty substances, sugars and alcohol.


dizziness
Symptom that can mean an impression of loss of balance (common sense) or, more strictly, a sense of rotation on oneself or the environment (medical sense).

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Pharmacovigilance : Déclarer un ou des effet(s) indésirable(s) lié(s) à l'utilisation d'un médicament

NOTICE

ANSM - Last updated: 10/05/2017

Name of the medicinal product

IPRAALOX 20 mg, gastro-resistant tablet

pantoprazole

framed

Please read this leaflet carefully before you start taking this medicine because it contains important information for you.

You should always take this medication exactly as prescribed in this leaflet or by your doctor or pharmacist.

· Keep this leaflet. You might need to read it again.

· Ask your pharmacist for advice or information.

· If you experience any side effects, talk to your doctor or pharmacist. This also applies to any side effects not mentioned in this leaflet. See section 4.

· You should contact your doctor if you experience no improvement or feel less well after 2 weeks.

What is in this leaflet?

1. What is IPRAALOX 20 mg Gastro-Resistant Tablets and in which cases is it used?

2. What should I watch out for before taking IPRAALOX 20 mg gastro-resistant tablets?

3. How to take IPRAALOX 20 mg, Gastro-resistant tablet?

4. What are the possible side effects?

5. How to store IPRAALOX 20 mg Gastro-Resistant Tablets?

6. Package contents and other information.

1. WHAT IS IPRAALOX 20 mg, gastro-resistant tablet AND WHAT IT IS USED FOR?

Pharmacotherapeutic group - Proton pump inhibitors, ATC code: A02BC02.

IPRAALOX contains an active substance, pantoprazole, which reduces the amount of acid produced in the stomach by blocking the "proton pump".

IPRAALOX is used for short-term treatment of symptoms of gastroesophageal reflux (eg heartburn, acid regurgitation) in adults.

Gastroesophageal reflux is the rise of acid from the stomach into the esophagus, which can become inflammatory and painful. This can cause symptoms such as burning in the chest going up to the throat (heartburn) and sour taste in the mouth (acid regurgitation).

Acid reflux and heartburn may disappear after a day of treatment with IPRAALOX. However this medication is not intended to provide immediate relief. It may be necessary to continue treatment for 2 or 3 consecutive days for symptom improvement.

2. BEFORE YOU TAKE IPRAALOX 20 mg Gastro-Resistant Tablets?

Do not take IPRAALOX:

· If you are allergic to pantoprazole, soy lecithin or any other component of this medication (see section 6).

· If you are taking a medication containing atazanavir (for the treatment of HIV infection), see section "Other medicines and IPRAALOX".

Warnings and Precautions

Talk to your doctor or pharmacist before taking IPRAALOX:

· If you have liver problems or jaundice (jaundice, yellowing of the skin or eyes);

· If you have taken continuously a treatment for heartburn or indigestion for 4 weeks or more;

· If you are over 55 and take a daily medication for indigestion delivered without a prescription;

· If you are over 55 years old and have symptoms of gastroesophageal reflux appearing for the first time or having recently changed;

· If you have a history of gastric ulcer or undergone stomach surgery;

· If you regularly visit your doctor because of serious disorder or illness;

· If you need to do an endoscopy or a urea breath test.

· If you have ever developed a skin reaction after treatment with a drug similar to IPRAALOX reducing gastric acid.

· If you need to do a specific blood test (Chromogranin A).

Consult your doctor immediately before or after taking IPRAALOX if you notice any of the following symptoms, which could be a sign of another more serious illness:

· Unintentional weight loss (not related to diet or exercise program),

· Vomiting, particularly if repeated,

· Vomiting blood, appearing under the aspect of dark coffee beans,

· Blood in the stool, which can be black or tarry,

· Difficulty or pain in swallowing,

· Pallor and weakness (anemia),

· Pain in the chest,

· Stomach ache,

· Severe and / or persistent diarrhea, as IPRAALOX has been associated with a slight increase in infectious diarrhea.

Your doctor may decide that you need to undergo additional tests.

If you have a blood test, tell your doctor that you are taking IPRAALOX.

Acid uproar and heartburn may disappear after one day of treatment with IPRAALOX. However this medication is not intended to provide immediate relief. You should not take it as a preventive measure.

If you suffer from heartburn or repeated and persistent indigestion, regular medical follow-up is recommended.

If you develop a rash, especially in areas exposed to the sun, consult your doctor as soon as possible, as you may need to stop your treatment with IPRAALOX. Do not forget to mention any other harmful effects, such as pain in your joints.

Children and Youth

Few safety data are available for this population, IPRAALOX should not be taken by a child or adolescent under 18 years of age.

Other drugs and IPRAALOX 20 mg, gastro-resistant tablet

Inform your doctor or pharmacist if you are taking, have recently taken or may take any other medicines.

IPRAALOX may affect the effectiveness of other medicines. Consult your doctor or pharmacist if you are taking a medication containing any of the following active ingredients:

· Atazanavir (used in the treatment of HIV infection). You should not take IPRAALOX if you are taking Atazanavir. See section "Never take IPRAALOX".

· Ketoconazole (used in the treatment of fungal infections).

· Warfarin and phenprocoumone (used to reduce blood clotting and prevent clots). Additional blood tests may be required.

· Methotrexate (used in the treatment of certain types of cancers, some forms of severe psoriasis and in rheumatoid arthritis) - if you are taking methotrexate, your doctor may temporarily discontinue your treatment with IPRAALOX because pantoprazole may increase methotrexate in the blood.

Do not take IPRAALOX with other drugs that limit the acidity of the stomach, such as another proton pump inhibitor (omeprazole, lansoprazole or rabeprazole) or anti-H2 (eg ranitidine, famotidine ).

You can however take IPRAALOX with an antacid (eg magaldrate, alginic acid, sodium bicarbonate, aluminum hydroxide, magnesium carbonate or combination of these substances) if necessary.

IPRAALOX 20 mg, Gastro-resistant tablet with food, drink and alcohol

Not applicable.

Pregnancy and breast feeding

You should not take this medication if you are pregnant or breast-feeding.

If you are pregnant or breastfeeding, think you may be pregnant or plan a pregnancy, ask your doctor or pharmacist for advice before taking this medicine.

Driving and using machines

If you experience any side effects such as dizziness or blurred vision, you should not drive or use machines.

IPRAALOX contains maltitol and soya lecithin

If your doctor has told you about an intolerance to some sugars, contact your doctor before taking this medicine.

IPRAALOX contains soya lecithin. If you are allergic to peanut or soy, do not take this medicine.

3. HOW TO TAKE IPRAALOX 20 mg gastro-resistant tablet?

Always take this medication exactly as prescribed in this leaflet or as directed by your doctor or pharmacist. In case of doubt, check with your doctor or pharmacist.

Take one tablet per day. Do not exceed this recommended dose of 20 mg pantoprazole per day.

You should take this medication for at least 2 or 3 consecutive days. Stop taking IPRAALOX when you no longer experience any symptoms. Acid uproar and heartburn may disappear after a single day of treatment with IPRAALOX. However this medication is not intended to provide immediate relief.

If your symptoms persist after 2 weeks of continuous treatment, see your doctor. Do not exceed 4 weeks of treatment without medical advice.

Take the tablet before a meal at the same time each day. Swallow the whole tablet with a glass of water. Do not crush or crush the tablet.

If you take more than IPRAALOX 20 mg, Gastro-resistant tablet you should:

Consult your doctor or pharmacist immediately. If possible, show your medication and this leaflet. There are no known symptoms of overdose.

If you forget to take IPRAALOX 20 mg, gastro-resistant tablet:

Do not take a double dose to make up for the missed dose. Take one tablet the next day at the usual time.

If you have any further questions on the use of this medication, ask your doctor or pharmacist.

If you stop taking IPRAALOX 20 mg, gastro-resistant tablet:

Not applicable.

4. WHAT ARE POSSIBLE SIDE EFFECTS?

Like all medicines, IPRAALOX can cause side effects, although not everybody gets them.

Tell your doctor immediately or contact the nearest hospital emergency department if you experience any of the following serious side effects. Stop immediately taking IPRAALOX, but take this leaflet and / or tablets with you.

Serious allergic reactions (rare frequency: may affect up to 1 in 1,000 people): hypersensitivity reactions, called anaphylaxis, anaphylactic shock and angioedema. Typical symptoms are swelling of the face, lips, mouth, tongue and / or throat, which may cause difficulty in breathing or swallowing, hives, severe dizziness with accelerated heartbeat, and abundant perspiration.

Serious skin reactions (indeterminate frequency: the frequency of which can not be estimated from the available data): swelling, skin peeling or blisters, lesions or bleeding around the eyes, nose, mouth or genitals and rapid deterioration of your general condition; rash, potentially accompanied by joint pain or rash as a result of exposure to the sun.

Other serious reactions (indeterminate frequency: effect whose frequency can not be estimated from the available data): yellowing of the skin and eyes (due to severe hepatic involvement) or renal disorders, eg pain on urination and pain at the bottom of the back with fever.

During treatment with the active substance of IPRAALOX, the following adverse effects were observed:

Common side effects (can affect up to 1 in 10 people)

Mild polyps in the stomach.

Uncommon side effects (can affect up to 1 in 100 people)

Headache, dizziness, diarrhea, nausea, feeling sick, vomiting, bloating and flatulence (gas), constipation, dry mouth, stomach pain and abdominal discomfort, rash or urticaria, itching, feeling weak, feeling exhausted or feeling general discomfort, sleep disorders, increased liver enzymes in the blood.

Uncommon side effects (can affect up to 1 in 1000 people)

Disorders of vision, such as blurred vision, joint pain, muscle pain, weight change, increased body temperature, swelling of the extremities, depression, increased bilirubin and fat in the blood (ascertained by a blood test), swelling of the breasts in man, high fever, abrupt decrease in white blood cells (visible in blood tests).

Very rare side effects (can affect up to 1 in 10,000 people)

Disorientation, decreased blood platelets, which may lead to bleeding or bruising, reduced white blood cell count, which can lead to more frequent infections, simultaneous lowering of all blood cells (red blood cells, white blood cells and platelets) (visible in blood tests).

Frequency unknown (effect whose frequency can not be estimated from the available data)

Hallucinations, confusion (especially in patients with a history of these disorders), decreased blood sodium and magnesium levels.

Declaration of side effects

If you experience any side effects, talk to your doctor or pharmacist. This also applies to any side effects not mentioned in this leaflet. You can also report adverse reactions directly via the national reporting system: National Agency for the Safety of Medicines and Health Products (ANSM) and network of Regional Centers of Pharmacovigilance - Website: www.ansm.sante.fr

By reporting adverse reactions, you are helping to provide more information about the safety of the drug.

5. HOW TO STORE IPRAALOX 20 mg gastro-resistant tablet?

Keep this medicine out of the reach and sight of children.

Do not use this medicine after the expiry date which is stated on the carton, label or vial. The expiry date refers to the last day of that month.

For tablets packed in a vial, IPRAALOX must be used within 3 months after the first opening of the vial.

No special storage conditions.

Do not throw any medicines into drains or rubbish. Ask your pharmacist to remove any medications you are no longer using. These measures will help protect the environment.

6. PACKAGE CONTENTS AND OTHER INFORMATION

What IPRAALOX 20 mg contains, gastro-resistant tablets

· The active substance is pantoprazole.

Each tablet contains 20 mg of pantoprazole (as pantoprazole sodium sesquihydrate).

· The other components are:

Core : maltitol (E 965), crospovidone type B, carmellose sodium, anhydrous sodium carbonate, calcium stearate .

Coating: polyvinyl alcohol, talc, titanium dioxide (E171), macrogol 3350, soy lecithin, yellow iron oxide (E172), anhydrous sodium carbonate, methacrylic acid / ethyl acrylate copolymer ) containing polysorbate 80 and sodium laurysulfate, triethyl citrate.

What is IPRAALOX 20 mg Gastro-resistant tablet and contents of the pack

This medication is in the form of yellow ovarian gastro-resistant tablets approx. 8.2 x 4.4 mm.

7 or 14 gastro-resistant tablets (OPA / Aluminum / PVC-Aluminum)

7 or 14 gastro-resistant tablets in a vial (HDPE).

Marketing Authorization Holder

SANOFI-AVENTIS FRANCE

82 AVENUE RASPAIL

94250 GENTILLY

Marketing Authorization Operator

SANOFI-AVENTIS FRANCE

82 AVENUE RASPAIL

94250 GENTILLY

Maker

SOFARIMEX - INDUSTRIA QUIMICA E FARMACEUTICA, SA

AV. DAS INDUSTRIAS - COLARIDE ALTO, AGUALVA

2735-213 CACEM

PORTUGAL

Or

ADVANCE PHARMA GMBH

WALLENRODER STRASSE 12-14,

13435 BERLIN

GERMANY

Or

SANOFI-AVENTIS SP. ZOO

UL. LUBELSKA 52,

35-233 RZESZOW,

POLAND

Names of the medicinal product in the Member States of the European Economic Area

Belgium: Maalox Control 20 mg gastro-resistant tablets

Estonia: Ipraalox

France: Ipraalox 20 mg gastro-resistant tablet

Greece: Ipraalox 20 mg Γαστροανθεκτικό δισκίο

Italy: Maalox Reflusso 20 mg compress gastroresistenti

Lithuania: Ipraalox 20 mg skrandyje neirios tabletės

Latvia: Ipraalox 20 mg zarnās šķīstošās tabletes

Netherlands: Ipraalox, 20 mg maagsapresistente tabletten

Portugal: Stomafor

Romania: Dicarbocalm Control 20 mg gastroenteritis comprimate

Slovenia: Ipraalox 20 mg gastroreztistne tablete

Slovak Republic: Ipraalox 20 mg gastrorezistentné tablety

The last date on which this leaflet was revised is:

To be completed later by the holder

Other

Detailed information on this medicine is available on the ANSM website (France).

Health education councils:

The following lifestyle and diet recommendations may also help relieve heartburn or other symptoms due to acid ascents.

· Avoid heavy meals.

· Eat slowly.

· Stop smoking.

· Reduce the consumption of alcohol or caffeine.

· Lose weight (in case of overweight).

· Avoid tight clothing or a loose belt.

· Avoid eating less than 3 hours before bedtime.

· Raise the head of the bed (in case of nocturnal disturbances).

· Reduce the consumption of foods that cause heartburn, including chocolate, peppermint, spearmint, greasy and fried foods, acid foods, spicy foods, citrus fruits and juices, tomatoes.

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Ipraalox is a drug indicated for the current term treatment of symptoms of gastroesophageal reflux.

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