Vitamin B12 Delagrange Cyanocobalamine 1000µg/2ml x 6 injectable ampoules, in our organic pharmacy, is indicated for people on vegetarian diets, chronically taking medications that reduce gastric acidity or for the elderly.
Vitamin B12 Delagrange 1000µg/2ml effectively treats severe vitamin B12 deficiencies, particularly those resulting from intestinal absorption disorders. It targets people suffering from Biermer's disease, who have undergone gastrectomy or intestinal resection, as well as those with Imerslund-Gräsbeck syndrome. Thanks to its concentrated cyanocobalamin formula, it ensures rapid replenishment of vitamin B12 reserves, often essential for maintaining the body's overall balance.
It also helps prevent and treat macrocytic anemia due to a lack of vitamin B12 in the diet. It represents an effective solution for patients on a strict vegan diet, the elderly, or anyone showing signs of persistent fatigue, pallor, or neurological disorders linked to hypovitaminosis B12. The optimal bioavailability of its injectable or drinkable form makes it a therapeutic ally of choice in these situations.
Cyanocobalamin, the active form of vitamin B12 used in this product, plays a key role in numerous biological functions. It plays an active role in the formation of red blood cells, the proper functioning of the nervous system, and DNA synthesis. By re-establishing normal vitamin B12 levels in the body, this treatment helps restore hematological balance and prevent the sometimes irreversible neurological complications of prolonged deficiency.
The treatment also acts on the neurological symptoms that can accompany a deficiency, such as tingling, memory loss and impaired concentration. Regular supplementation, initiated at the very first signs, can often halt the progression of disorders and improve the patient's quality of life. Vitamin B12 Delagrange acts as a genuine cellular energy recharge.
In frail or elderly people, this treatment helps reduce the risk of falls, mental confusion and cognitive decline. Cyanocobalamin also acts indirectly on the metabolism of homocysteine, an amino acid whose accumulation can increase cardiovascular risk. It therefore supports overall health and preserves healthy cardiovascular and cerebral function.
In short, this treatment acts as a fundamental lever for restoring the biological balances disturbed by vitamin B12 deficiency. It strengthens the immune system, restores energy, protects nerves and optimizes blood cell production. Its injectable or drinkable formulation can be adapted to all clinical situations, whether for curative or maintenance treatment.
You can combine this product with an iron or folic acid nutritional supplement, if recommended by your healthcare professional, to optimize the correction of your anemia.
Importance of Vitamin B12
Vitamin B12 plays a crucial role in the formation of red blood cells and in supporting the nervous system as an essential cofactor in the production of myelin, a substance fundamental to the insulation of nerve fibers. It also helps maintain the metabolic balance of homocysteine in cooperation with other B vitamins. In addition, vitamin B12 is indispensable for energy metabolism, providing energy for daily activities.
The liquid form of vitamin B12 offers flexibility of use, making it easy to add to drinks or food. Its pleasant taste makes it a popular option for those who prefer to avoid capsules or tablets. This convenience makes it a practical choice for integrating vitamin B12 into your daily supplementation routine.
We also offer Vitall+ Vitamin B8 1000µg 60 vegetarian capsules, at the best price in our online pharmacy.
Directions for use and dosage
You can administer Vitamin B12 Delagrange 1000µg/2ml either by intramuscular injection or orally, depending on the origin of the deficiency.
For deficiencies due to poor absorption (e.g. Biermer's disease or intestinal disorders), prefer the injectable route. Start with 1 ampoule a day for 10 days, or 1 ampoule 3 times a week for around 3 weeks, for a total of 10 ampoules for the attack phase. Then continue with 1 ampoule per month for maintenance.
For deficiencies linked to a lack of dietary intake, opt for the oral route. Start with 1 ampoule a day for 15 to 30 days, then continue with 1 ampoule every 10 days for maintenance.
Give your opinion on the advice for use and dosage of Vitamin B12 Delagrange 1000µg/2ml with our partner Avis Vérifiés after your purchase.
Precautions for use
Cyanocobalamin, Dilute Hydrochloric Acid, Sodium Chloride, Water for Injectable Preparations.
Nutritional value of Vitamin B12 Delagrange 1000µg/2ml
For a 2 ml ampoule:
Cyanocobalamin: 1000 µg
Presentation
One box contains 6 x 2 ml ampoules of injectable or drinkable solution. Each ampoule is ready-to-use for fast, easy administration.
Pharmacists regularly stress the benefits of rapid treatment with cyanocobalamin in cases of diagnosed deficiency, particularly in elderly patients or those on a vegan diet. From a naturopathic point of view, vitamin B12 is an essential cofactor in cellular energy production, particularly beneficial for people prone to chronic fatigue or mood disorders. Many patients report a rapid improvement in vitality after just a few days of treatment. This product is part of a strong trend towards preventing silent deficiencies before they compromise overall health. In fact, regular assessment of B12 levels is recommended as part of preventive care programs.
Pharmacovigilance Report an adverse drug reaction(s)
ANSM - Updated on : 14/02/2023
VITAMIN B12 DELAGRANGE 1000 micrograms/2 ml, solution for injection (IM) and drinking
Cyanocobalamin
Please read this leaflet carefully before using this medicine, as it contains important information for you.
You must always use this medicine in strict accordance with the information provided in this leaflet or by your doctor or pharmacist.
- Keep this leaflet. You may need to read it again.
- Ask your pharmacist for any advice or information you may need.
- If you experience any side effects, talk to your doctor or pharmacist. This also applies to any side effects not mentioned in this leaflet. See section 4.
- You should contact your doctor if you do not feel any improvement or if you feel less well.
What does this leaflet contain?
1. What is VITAMIN B12 DELAGRANGE 1000 micrograms/2 ml, solution for injection (IM) and drinking and what is it used for?
2. What do I need to know before taking VITAMIN B12 DELAGRANGE 1000 micrograms/2 ml, solution for injection (IM) and for drinking?
3. How to use VITAMIN B12 DELAGRANGE 1000 micrograms/2 ml, injectable (IM) and drinkable solution?
4. What are the possible side effects?
5. How to store VITAMIN B12 DELAGRANGE 1000 micrograms/2 ml, solution for injection (IM) and oral use?
6. Package contents and other information.
Pharmacotherapeutic class: ANTIANEMIC - VITAMIN B12 ATC code: B03BA01
This medicine contains vitamin B12.
It is used :
- by intramuscular injection to make up for vitamin B12 deficiencies that the body no longer absorbs, in people suffering from Biermer's disease or Imerslund's disease, or who have had their stomach or part of their intestine removed.
- orally (drinkable ampoule) to treat anemia (reduced number of red blood cells in the blood) caused by a diet low in vitamin B12, in people following a diet without meat, dairy products, egg or fish for more than 4 years (strict vegans).
Never use VITAMIN B12 DELAGRANGE 1000 micrograms/2 ml, solution for injection (IM) and for drinking:
- if you are allergic to vitamin B12 and related substances (cobalamins), or to any of the other components of this medicine listed in section 6.
- if you have Leber's hereditary optic neuropathy (see "Warnings and Precautions" below).
Warnings and precautions
Talk to your doctor or pharmacist before using VITAMIN B12 DELAGRANGE 1000 micrograms/2 ml, solution for injection (IM) and for drinking.
This medicine should not be used if you have a hereditary disease of optic nerve malfunction manifested by a sudden drop in vision, called Leber's hereditary optic neuropathy, as there is an increased risk of potentially rapid and severe optic neuropathy (destruction of optic nerve fibers).
Other medicinal products and VITAMIN B12 DELAGRANGE 1000 micrograms/2 ml, solution for injection (IM) and drinking
Tell your doctor or pharmacist if you are taking, have recently taken or may take any other medicines, especially those used to reduce stomach acidity (gastric antisecretory drugs).
In the event of prolonged treatment, the reduction of stomach acidity by these drugs may reduce the digestive absorption of vitamin B12.
Pregnancy and breast-feeding
If you are pregnant or breastfeeding, think you may be pregnant or are planning to become pregnant, ask your doctor or pharmacist for advice before taking this medicine.
Use of this drug should be avoided during pregnancy. If you discover that you are pregnant during treatment, consult your doctor immediately, as only he or she can decide whether to continue treatment.
This drug passes into breast milk. Its use during breast-feeding is not recommended. If its use is necessary, breast-feeding must be stopped.
VITAMIN B12 DELAGRANGE 1000 micrograms/2 ml, solution for injection (IM) and drinking contains sodium.
This medicine contains less than 1 mmol (23 mg) of sodium per ampoule, i.e. it is essentially "sodium-free".
Always use this medicine exactly as prescribed by your doctor. Check with your doctor or pharmacist if in doubt.
- Treatment of vitamin B12 deficiency (intramuscular injection):
o To start treatment: 1 ampoule a day for 10 days or 1 ampoule 3 times a week for just over 3 weeks, i.e. 10 ampoules in all.
o Then, as a maintenance treatment: one ampoule per month.
- Treatment of anemia caused by low vitamin B12 intake in strict vegans (oral) :
o To begin treatment: 1 ampoule per day for 15 days to 1 month.
o Then, as a maintenance treatment: 1 ampoule every 10 days.
Method and route of administration
The way you use this drug depends on the disease being treated (see paragraph 1):
- or by intramuscular injection: it is injected into a muscle;
- orally: in this case, pour the contents of the vial into a glass of water and drink.
To open the vial :
Hold lampoule firmly. Grasp the lampoule head between thumb and index finger, then press backwards.
Duration of treatment
Follow your doctor's instructions.
If you have used more VITAMIN B12 DELAGRANGE 1000 micrograms/2 ml, solution for injection (IM) and for drinking than you should have :
Consult your doctor or pharmacist.
If you have any further questions about the use of this medicine, ask your doctor or pharmacist.
4. WHAT ARE THE POSSIBLE SIDE EFFECTS?
Like all medicines, this drug may cause undesirable effects, but they do not occur systematically in everyone.
Discontinue your treatment and consult your doctor immediately if you experience an allergic reaction. It may manifest itself as itching, eczema, urticaria, reddening of the skin, or even localized skin lesions which may progress to destruction of the skin cells (necrosis), swelling (angioedema), or allergic shock (intense generalized malaise).
The following adverse reactions may occur with undetermined frequency (frequency cannot be estimated on the basis of available data):
- Allergic reaction
- Acne
- Pain at the injection site
- Red coloration of urine (due to elimination of vitamin B12 in the urine).
Reporting side effects
If you experience any side effects, please tell your doctor or pharmacist. This also applies to any side effects not mentioned in this leaflet. You can also report adverse reactions directly via the national reporting system: Agence nationale de sécurité du médicament et des produits de santé (ANSM) and the network of Centres Régionaux de Pharmacovigilance - Website: https://signalement.social-sante.gouv.fr.
By reporting adverse reactions, you are helping to provide more information on drug safety.
Keep out of sight and reach of children.
Do not use this medicine after the expiration date indicated on the packaging. The expiration date refers to the last day of that month.
Store at a temperature not exceeding 25°C and protect from light.
Do not dispose of any medicine in the sewer or with the household waste. Ask your pharmacist to dispose of any medicines you no longer use. These measures will help protect the environment.
6. CONTENTS AND OTHER INFORMATION
What VITAMIN B12 DELAGRANGE 1000 micrograms/2 ml, injectable (IM) and drinkable solution contains
- The active substance is :
Cyanocobalamin.......................................................................................................... 1000 µg
For one 2-ml ampoule.
- The other components are :
Dilute hydrochloric acid, sodium chloride (see section 2), water for injection.
This medicine is available as an injectable (IM) and drinkable solution in 2 ml ampoules. Boxes of 6 and 48 ampoules.
Not all presentations may be marketed.
Marketing authorization holder
ZENTIVA FRANCE
35 RUE DU VAL DE MARNE
75013 PARIS
Marketing authorization holder
ZENTIVA FRANCE
35 RUE DU VAL DE MARNE
75013 PARIS
DELPHARM DIJON
6 BOULEVARD DE LEUROPE
21800 QUETIGNY
Or
FAMAR HEALTH CARE SERVICES MADRID S.A.U
AVDA DE LEGANES N° 62
ALCORCON
28925 MADRID
Spain
Product names in member states of the European Economic Area
Not applicable.
This leaflet was last revised on :
To be completed subsequently by the holder
Detailed information on this drug is available on the ANSM (France) website.
This medicine contains vitamin B12, essential for bone marrow function (which manufactures blood cells).
It is used in the treatment of certain forms of anemia due to defective absorption of vitamin B12 by the intestine or insufficient dietary intake.
Prices do not include dispensing fees.
| p amp | |
| Cyanocobalamin (vitamin B12) | 1,000 μg |
Tell your doctor if you are taking a gastric antisecretory drug (cimetidine, famotidine, esomeprazole, lansoprazole, omeprazole, pantoprazole, rabeprazole, etc.) for prolonged treatment (several years).
The effect of this drug during pregnancy or breast-feeding is not well known: only your doctor can assess the possible risk of its use in your case.
The solution can be drunk or injected intramuscularly.
Under treatment, red coloration of the urine is normal: this is linked to the elimination of vitamin B12.
Acne, allergic reaction (itching, hives, eczema, angioedema, even anaphylactic shock).
Pain at injection site.
Skin condition linked to sebum retention, forming comedones (blackheads and microcysts). These are the site of bacterial proliferation and transform into pustules.
See article: Acne
Skin reaction (itching, pimples, swelling) or general discomfort following contact with a particular substance, the use of a medicine or the ingestion of a food. The main forms of allergy are eczema, urticaria, asthma, angioedema and allergic shock (anaphylactic shock). Food allergy can also lead to digestive disorders.
A drop in the level of hemoglobin in the blood, most often reflected by a drop in the number of red blood cells. Iron is essential for hemoglobin synthesis. Iron deficiency due to pregnancy, vegetarian diet, heavy or repeated bleeding (menstruation) is a frequent cause of anemia. Other, rarer causes are linked to deficiencies in B vitamins.
A condition that has been cured or is still evolving. The antecedent may be personal or familial. Antecedents are the history of a person's health.
Drug that reduces digestive secretions. Anti-H2-type gastric antisecretories are used to treat ulcers and gastritis, while intestinal antisecretories are used to treat certain forms of diarrhea.
Reduction in the volume of an organ or limb, due to aging, disease or lack of blood supply.
Allergic shock manifested by a sudden drop in blood pressure, due to extreme dilation of the blood vessels. It occurs after contact with an allergenic substance (food, insect sting, injection or absorption of medication).
Skin disease manifested by pimples and intense itching. Eczema may be due to contact with an allergenic substance (contact eczema) or to a genetic predisposition (atopic eczema).
See article: Atopic dermatitis (atopic eczema)
Abbreviation for intramuscular.
Injection of a drug into a muscle, usually in the buttock. The effect of the drug, which only gradually enters the bloodstream, is delayed but prolonged. The skin must be disinfected beforehand, as this deep injection exposes it to the risk of abscess. Painful injections depend above all on the nature of the product used. This route of administration is contraindicated for haemophiliacs and people on anticoagulant therapy, as it exposes them to the risk of buttock haematoma.
Abbreviation: IM.
Substance found inside certain bones. The bone marrow is responsible for producing blood and immune cells: red blood cells, white blood cells and blood platelets.
Allergic reaction generally affecting the face. Quincke's edema is characterized by swelling that can be spectacular. The eyelids are often the first to be affected. In rare cases, when the swelling reaches the throat, respiratory problems may occur and urgent treatment is required.
Reaction caused by the body's hypersensitivity to a drug. Allergic reactions can take a variety of forms: urticaria, angioedema, eczema, measles-like rash and so on. Anaphylactic shock is a generalized allergic reaction that causes a sudden drop in blood pressure.
See article: Can you be allergic to medication?
A rash of pimples on the skin, most often caused by allergies. Pimples resemble nettle stings and vary in color from pale pink to red. Hives can appear or disappear in a matter of minutes, causing intense itching; they can be localized or generalized to the entire skin surface.
A substance essential for the body's growth and proper functioning. Vitamin requirements are normally covered by a varied diet. In developed countries, only vitamin D deficiency in young children or elderly people with little exposure to sunlight justifies systematic supplementation. Intake in excess of requirements, particularly through medication, can lead to overdosage and various disorders (mainly vitamins A and D).
See article: Vitamins.
In France, according to a 2020 study, the French are increasingly aware of the consequences of their diet on their health and the environment. Indeed, dietary changes are visible, and some are turning to a vegetarian or vegan diet (2.2% of the population). Others are even opting for the Vegan lifestyle, which is built around respect for ethical and environmental…
Read the article on the blogThe vegan movement has taken the food world by storm over the last decade. More and more people are adopting a plant-based diet for environmental, ethical and health reasons. But are vegan dieters protein deficient? That's the question we'll address in this article. Are Vegan dieters protein deficient? This is a subject that is the subject of much debate. Many…
Read the article on the blogAnemia is characterised by a drop in the number of red blood cells or their haemoglobin content. It reduces the blood's ability to carry oxygen. This condition can lead to fatigue, shortness of breath and other symptoms that affect quality of life. Fortunately, there are effective treatments and preventive measures. Diet is one of the main approaches to anaemia. Anti-anaemia"…
Read the article on the blog
