Difrarel E is an over-the-counter medication indicated for the treatment of twilight and night vision problems, as well as nearsightedness. It is traditionally recommended for the prevention of cataracts (lens opacity).
When your eyes get tired as soon as it gets dark, when lights dazzle you, or when your night vision becomes less clear, Difrarel E can make all the difference. This eye health supplement is specially formulated to support visual health, particularly in cases of progressive nearsightedness or vision problems related to difficulty adjusting to darkness. It is a supplemental treatment that naturally supports twilight and night vision, particularly useful in cases of eye strain or prolonged screen exposure.
The secret to Difrarel E lies in its unique combinationof blueberry anthocyanoside extract and vitamin E in the form ofalpha-tocopherol acetate. These two active ingredients work synergistically to strengthen ocular microcirculation, protect tissues from free radicals responsible for oxidative stress, and improve visual comfort, especially in low-light environments. This represents a true targeted antioxidant action, which is invaluable for tired eyes.
Anthocyanosides, extracted from blueberries, are known for their ability to improve night vision thanks to their beneficial effect on the retina and the eye’s capillaries. At the same time, vitamin E acts as a cellular protector, limiting the degeneration of eye cells and helping to preserve sensitive visual structures. The result: sharper, more stable vision with greater comfort at the end of the day.
Intended for adults with nearsightedness or evening vision difficulties, this treatment is well-tolerated, with few reported side effects. It is easy to take and suitable for monthly treatment regimens, making it compatible with a comprehensive approach to eye health as part of enhanced visual hygiene.
As a complement to a healthy lifestyle, Difrarel E fits perfectly into a preventive and natural approach to age-related eye changes. It may be recommended for people who work at computer screens, night drivers, or those experiencing impaired vision at dusk. Thanks to its natural, targeted ingredients, it effectively helps enhance visual acuity, reduce eye strain, and improve vision in low light.
To maximize the benefits—especially for dry or sensitive eyelids—you can combine it with Ilast Hydraclean Moisturizing Eyelid Gel, a complementary treatment designed to maintain the balance of the tear film.
Instructions for Use of Difrarel E
Difrarel E is taken orally in the form of coated tablets, which should be swallowed whole with a glass of water without chewing. The usual recommended dosage is 3 to 6 tablets per day, to be taken as directed by your doctor or pharmacist. The treatment is designed as 20-day courses per month, which may be repeated as needed.
Share your feedback on the usage instructions and dosage of Difrarel E with our partner Avis Vérifiés after your purchase.
Precautions
Blueberry Anthocyanoside Extract, D-Alpha-Tocopherol Acetate, Gelatin, Silicic Acid, Microcrystalline Cellulose, Sodium Croscarmellose, Anhydrous Colloidal Silica, Gum Arabic, Sucrose, Corn Starch, Talc, Titanium Dioxide, Opaglos 6000
Nutritional Values of Difrarel E
Each coated tablet contains:
Packaging
Difrarel E is available in boxes of 24 or 60 coated tablets, to be taken as a monthly course of treatment. The box is designed for easy use, with tablets that are convenient to take on the go.
To maximize the effectiveness of Difrarel E as part of a natural eye care routine, several simple steps can be incorporated alongside the treatment. Remember to rest your eyes every 20 minutes of screen time, practice focusing exercises, or incorporate anthocyanin-rich berries, such as blueberries or blackberries, into your diet.
From a naturopathic perspective, combining it with antioxidant-rich herbs, such as ginkgo biloba or eyebright, can improve microcirculation and strengthen retinal capillaries. Similarly, zinc and vitamin A supplements can support low-light vision. Also remember tokeep your eyes hydrated byusing artificial tears if your eyes feel gritty at the end of the day.
Finally, adopt good lighting habits: opt for indirect lighting, avoid glare, and wear blue-light-filtering glasses if you work at a computer screen. These are simple steps that, when combined with Difrarel E, enhance your visual comfort every day.
Pharmacovigilance Report an adverse drug reaction(s)
NOTICE
ANSM - Updated on : 05/08/2024
Product name
DIFRAREL E, coated tablet
Blueberry anthocyanosid extract / Dalpha-tocopherol acetate
Box
Please read this leaflet carefully before taking this medicine, as it contains important information for you.
You must always take this medicine exactly as instructed in this leaflet or by your doctor or pharmacist.
- Keep this leaflet. You may need to read it again.
- Ask your pharmacist for advice and information.
- If you experience any side effects, talk to your doctor or pharmacist. This also applies to any side effects not mentioned in this leaflet. See section 4.
- You should contact your doctor if you do not feel any improvement or if you feel less well.
What does this leaflet contain?
1. What is DIFRAREL E, coated tablet and what is it used for?
2. What do I need to know before taking DIFRAREL E, coated tablet?
3. How do I take DIFRAREL E, coated tablet?
4. What are the possible side effects?
5. How do I keep DIFRAREL E, coated tablet?
6. Package contents and other information.
1. WHAT IS DIFRAREL E, coated tablet AND WHAT IS IT USED FOR?
Pharmacotherapeutic class: OPHTALMOLOGICAL / VASCULOPROTECTIVE DRUGS (S: sensory organs) - ATC code: S01X
This drug is indicated for the adjunctive treatment of twilight and night vision disorders and myopia.
2. WHAT DO I HAVE TO KNOW BEFORE TAKING DIFRAREL E, coated tablet?
Never take DIFRAREL E, coated tablet:
- if you are allergic to the active substances or to any of the other ingredients of this medicine, as listed in section 6.
IF IN DOUBT, ASK YOUR DOCTOR OR PHARMACIST.
Warnings and precautions
Talk to your doctor or pharmacist before taking DIFRAREL E, coated tablet. In the event of sudden visual disturbance or worsening of a pre-existing visual disturbance, it is necessary to consult your doctor.
Children
Not applicable.
Other medicines and DIFRAREL E, coated tablet
Tell your doctor or pharmacist if you are taking, have recently taken or may take any other medicines.
DIFRAREL E, coated tablet with food and drink
Not applicable.
Pregnancy and breast-feeding
This medicine should not be used during pregnancy.
If you are pregnant or breastfeeding, think you may be pregnant or are planning to become pregnant, ask your doctor or pharmacist for advice before taking this medicine.
Do not use this product while breast-feeding.
In general, always ask your doctor or pharmacist for advice before taking any medicine during pregnancy or when breast-feeding.
Driving and using machines
Not applicable.
DIFRAREL E, coated tablet contains sucrose and sodium.
If your doctor has informed you that you are intolerant to certain sugars, contact your doctor before taking this medicine.
This medicine contains less than 1 mmol (23 mg) of sodium per tablet, i.e. it is essentially "sodium-free".
3. HOW DO I TAKE DIFRAREL E, coated tablet?
Always take this medicine exactly as prescribed by your doctor or pharmacist. Check with your doctor or pharmacist if in doubt.
Dosage :
The recommended dose is 3 to 6 tablets a day.
Treatment should be carried out in courses of 20 days per month, then repeated if necessary.
Method and route of administration :
Oral route.
Tablets are to be swallowed, without chewing, with a glass of water.
Duration of treatment :
Treatment should be taken in courses of 20 days per month, and repeated if necessary.
Follow your doctor's advice.
If you have taken more DIFRAREL E, coated tablet than prescribed
No cases of overdose have been reported. However, excessive use may aggravate undesirable effects.
If you think you have taken more Difrarel E, coated tablet than you should have, please contact your doctor or pharmacist.
If you forget to take DIFRAREL E, coated tablet
Not applicable.
If you stop taking DIFRAREL E, coated tablet
Not applicable.
4. WHAT ARE THE POSSIBLE SIDE EFFECTS?
Like all medicines, this drug may cause undesirable effects, but they do not occur systematically in everyone.
Possible side effects include
- Minor digestive disorders.
Reporting side effects
If you experience any side effects, please tell your doctor or pharmacist. This also applies to any side effects not mentioned in this leaflet. You can also report adverse reactions directly via the national reporting system: Agence nationale de sécurité du médicament et des produits de santé (ANSM) and the network of Regional Pharmacovigilance Centers.
By reporting adverse reactions, you are helping to provide more information on drug safety.
5. HOW TO CONSERVE DIFRAREL E, coated tablet?
Keep out of sight and reach of children.
Do not use this medicine after the expiration date indicated on the outer packaging. The expiration date refers to the last day of that month.
Do not dispose of any medicine down the drain or in the household waste. Ask your pharmacist to identify any medicines you no longer use. These measures will help protect the environment.
Store at a temperature not exceeding 30°C.
6. CONTENTS AND OTHER INFORMATION
What DIFRAREL E, coated tablet contains
- The active ingredients are :
Bilberry anthocyanidin extract ............................................................................... 50,000 mg
Alpha-tocopherol acetate concentrate - powder form ...................................... 50,000 mg
For one coated tablet.
- Other components are :
Gelatin, silicic acid, microcrystalline cellulose, croscarmellose sodium, colloidal anhydrous silica, gelatin, gum arabic, sucrose, corn starch, talc, titanium dioxide (E171), Opaglos 6000.
What DIFRAREL E, coated tablet is and what it contains
This medicine is a coated tablet.
Box of 24 or 60 coated tablets.
Marketing authorization holder
BIOCODEX
22 RUE DES AQUEDUCS
94250 GENTILLY
Marketing authorization holder
BIOCODEX
22 RUE DES AQUEDUCS
94250 GENTILLY
Manufacturer
FAMAR L'AIGLE
ZONE INDUSTRIELLE N°1,
ROUTE DE CRULAI
61300 L'AIGLE
France
Or
CENEXI - FONTENAY SOUS BOIS
52 rue Marcel et Jacques Gaucher
94120 FONTENAY SOUS BOIS
France
Drug names in member states of the European Economic Area
Not applicable.
The last date on which this leaflet was revised was :
October 2020
Other
Detailed information on this drug is available on the ANSM (France) website.
Ce médicament associe un extrait de plante qui a un effet protecteur sur les vaisseaux sanguins et de la vitamine E.
Il est utilisé dans le traitement d'appoint de la myopie ou des troubles de la vision nocturne.
Les prix mentionnés ne tiennent pas compte des « honoraires de dispensation » du pharmacien.
| p cp | |
| Myrtille, extrait anthocyanosidique | 50 mg |
| Alpha-tocophérol (Vitamine E) | 50 mg |
L'effet de ce médicament pendant la grossesse ou l'allaitement est mal connu. L'évaluation du risque éventuel lié à son utilisation est individuelle : demandez conseil à votre pharmacien ou à votre médecin.
Les comprimés doivent être avalés avec un verre d'eau.
3 à 6 comprimés par jour, 20 jours par mois.
Trouble de la vision qui projette l'image d'un objet en avant de la rétine. L'image formée sur la rétine est floue comme si l'il était trop profond : la personne a du mal à voir les objets situés au loin. Le port de lunettes ou de lentilles de contact est nécessaire lorsque l'accommodation du cristallin ne parvient pas à compenser ce défaut.
Substance indispensable à la croissance et au bon fonctionnement de l'organisme. Les besoins en vitamines sont normalement couverts par une alimentation variée. Dans les pays développés, seule la carence en vitamine D, chez le jeune enfant ou le vieillard peu exposés au soleil, justifie une supplémentation systématique. Un apport supérieur aux besoins, par des médicaments notamment, peut être à l'origine d'un surdosage et de troubles divers (vitamines A et D essentiellement).
Consultez l'article : Les vitamines.
