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What is enoxolone and why is it used in dermatology and pharmacology?
Enoxolone, also known as glycyrrhetinic acid, is an active compound extracted from licorice (Glycyrrhiza glabra). It is recognized for its powerful anti-inflammatory, soothing and healing properties, making it an ingredient of choice in many dermatological and medicinal treatments.
With effects similar to those of cortisone, but without its major side effects, enoxolone is used to relieve skin inflammation, protect the gastric mucosa and reduce allergic reactions. It is used in soothing creams, anti-redness treatments, gastrointestinal medicines and toothpastes.
How does enoxolone benefit the skin?
Enoxolone is an essential dermatological active ingredient for treating inflammatory and irritative skin conditions. Its main benefits are to
Soothes redness and irritation: Ideal for sensitive, reactive skin or skin prone to inflammation (eczema, psoriasis, atopic dermatitis).
Reduces allergic reactions: blocks the release of inflammatory mediators, reducing itching and redness.
Healing and regenerating: Accelerates skin repair, ideal for superficial lesions and light burns.
Anti-acne and sebum-regulating: Reduces the inflammation of pimples and regulates sebum production in skincare products for oily, acne-prone skin.
Protects against external aggressors: reinforces the skin barrier, limiting the effects of oxidative stress, pollution and UV rays.
Enoxolone is often found in soothing creams, anti-redness serums and skincare products for sensitive skin, offering a natural alternative to dermocorticoids.
Is enoxolone effective against redness and rosacea?
Yes, thanks to its anti-inflammatory and soothing properties, enoxolone is an excellent active ingredient for reducing redness and skin sensitivity:
Reduces flushing and diffuse redness associated with rosacea.
Reduces the burning and stinging sensation of reactive skin.
Soothes dilated vessels and calms inflammation in couperose-prone skin.
Used topically, it gently balances and protects fragile skin.
Is enoxolone beneficial for mucous membranes and the digestive system?
Yes, enoxolone is widely used in gastroenterology for its protective effects on the gastric mucosa. In particular, it is recommended for :
Relieve heartburn and acid reflux by forming a protective barrier over the stomach.
Reduce peptic ulcers thanks to its healing and anti-inflammatory action.
Reduce intestinal inflammation (colitis, irritable bowel syndrome).
Enoxolone can be found in certain medications for gastric disorders, where it is combined with other mucosa-protecting agents.
Is enoxolone effective in oral hygiene?
Yes, enoxolone is commonly used in toothpastes and mouthwashes for its anti-inflammatory and antibacterial properties. It helps to :
Soothe irritated gums and prevent bleeding.
Reduce mouth ulcers and mouth sores.
Protect against gum infections by inhibiting bacterial growth.
Enoxolone toothpastes are particularly recommended for sensitive or inflamed gums.
How is enoxolone used?
Enoxolone is used in a wide range of products for skin care, digestive comfort and oral hygiene:
Creams and serums for sensitive and inflamed skin.
Anti-acne gels and lotions to soothe red, inflamed pimples.
Gastrointestinal medicines to relieve heartburn and protect the stomach.
Toothpastes and mouthwashes to soothe sensitive gums.
What is the recommended dosage for enoxolone supplementation?
Dosages vary according to use:
For cutaneous application: Use a cream containing 0.5 to 1% enoxolone, 1 to 2 times a day on sensitive areas.
As a gastrointestinal supplement: Dosages vary, so follow medical recommendations.
Oral hygiene: Use enoxolone-enriched toothpaste morning and night for optimum protection.
Are there any contraindications to using enoxolone?
Although enoxolone is well tolerated, certain precautions are necessary:
People with high blood pressure: Enoxolone can retain sodium and cause a slight rise in blood pressure.
Pregnant and breast-feeding women: Its use should be limited due to its potential effects on electrolyte balance.
Infants: Apply to the skin with caution, under medical supervision.
Enoxolone should not be used for long periods without medical advice, particularly for internal use.
Can enoxolone be combined with other active ingredients to boost its efficacy?
Yes, enoxolone can be combined with other ingredients for synergistic action:
With hyaluronic acid: for a reinforced soothing and moisturizing effect on the skin.
With bisabolol and allantoin: For maximum reduction of redness and skin inflammation.
With probiotics: To optimize protection of the intestinal mucosa.
With zinc and copper: for improved healing and protection of acne-prone skin.
These combinations optimize the soothing and repairing effects of enoxolone.