Through Soin et Nature, the Alfa Sigma laboratory—now part of the Alfasigma Group—offers innovative pharmaceutical solutions based on recognized expertise in gastroenterology, metabolism, and digestive health. Through products such as Météoxane, Esoxx-One, and Parapsyllium, this product line aims to effectively relieve functional digestive disorders by combining scientific rigor, optimal tolerability, and ease of daily use.
More detailsFounded in 1948 in Bologna, Italy, Alfa Sigma is a long-standing player in the European pharmaceutical industry. Through steady growth, the company has gained international recognition in the research, development, and marketing of medications designed to improve patients’ quality of life across various therapeutic areas.
In 2015, Alfa Sigma merged with the Sigma-Tau Group, giving rise to Alfasigma, now one of the top five players in the Italian pharmaceutical market. Building on this synergy, the group has established itself globally as an innovative pharmaceutical company focused on patients’ specific therapeutic needs, with expertise in gastroenterology, cardiometabolism, orthopedics and rheumatology, diabetology, as well as clinical nutrition and family medicine.
Since its founding, Alfa Sigma has been engaged in a structured process of internationalization. As early as 1989, a dedicated division was created to oversee global operations. In the years that followed, the group established a strong foothold in several countries:
Today, Alfasigma operates in more than 90 countries, with several production and research centers, including its major industrial site in Alanno, in the Abruzzo region of Italy.
Alfa Sigma’s—now Alfasigma’s—mission is centered on therapeutic innovation. The group continuously invests in the discovery of new molecules, formulation development, and the integration of emerging technologies to ensure optimal clinical efficacy combined with a high level of safety.
The company’s priorities include:
Alfa Sigma products cover a wide range of medical areas, for both treatment and prevention.
Calciprat Vitamin D3 1000 mg / 800 IU is indicated for the prevention and treatment of vitamin Dand calcium deficienciesin at-risk individuals (the elderly, postmenopausal women, and patients with osteoporosis). It comes in the form of chewable tablets, which help ensure treatment adherence.
Several dosages are available (400 IU, 800 IU) in packs of 30 or 60 tablets, tailored to age, physiological condition (growth, pregnancy, breastfeeding), or specific clinical needs.
Surfortan is a supplementary medication designed to combat asthenia. It combines essential amino acids, vitamin B6, potassium, and phosphorus, providing general metabolic support in cases of temporary fatigue. It is indicated for adults and children ages 6 and older. The oral ampoule form, to be taken diluted in a little water before meals, is convenient and rapidly absorbed.
Météoxane – Antiflatulent and antispasmodic
Météoxane, which contains simethicone, is indicated for the treatment of abdominal pain associated withbloating, intestinal gas, and mild diarrhea. Its mechanical action creates a protective film on the mucous membranes and facilitates the expulsion of gas. It comes in capsule form and is generally taken before meals.
Parapsyllium – Natural bulk-forming laxative
Made from blond psyllium, Parapsyllium is a mild laxative that works by increasing stool bulk. It is recommended for thesymptomatic treatment of occasionalconstipation. This medication is particularly suitable for patients seeking a plant-based solution. However, its use is contraindicated in cases of intestinal obstruction or unexplained abdominal pain.
Bacilor – Restoring Balance to the Intestinal Flora
Bacilor is a microbial anti-diarrheal agent designed to restore disrupted intestinal flora. It is used as an adjunctive treatment, in addition to appropriate rehydration. Available in capsule or powder packet form, it is well tolerated, even by children.
Esoxx One – Treatment for Gastroesophageal Reflux
Esoxx One contains a combination of chondroitin sulfate andhyaluronic acid, which forms a protective barrier on the esophageal mucosa. It is recommended for acid reflux to relieve heartburn and prevent chronic irritation.
Alfa Sigma’s manufacturing sites meet strict European standards for quality, safety, and pharmaceutical traceability. The main plant in Alanno is certified under Good Manufacturing Practices (GMP) and enables the large-scale production of medications for the international market.
The company is also committed toensuring access to treatment. Its products—whether prescription or over-the-counter—are priced competitively to ensure they are available to as many people as possible, particularly in developing countries.
With over 70 years of experience, a presence in more than 90 countries, and a rich and diversified therapeutic portfolio, Alfa Sigma—now part of the Alfasigma Group—has established itself as a key player in human health. By combining innovation, scientific expertise, and social commitment, the company addresses the current challenges of modern medicine, both in the prevention and treatment of common and chronic conditions.
Through its approach grounded in research, quality, and a close alignment with clinical needs, Alfa Sigma continues to improve the daily lives of patients around the world.
