400MG TABLETS 14 ADVILTAB

ADVILTAB 400MG COMPRIMES 14 View larger

3400938171150

Pfizer Pfizer

ADVILTAB 400MG TABLET 14 for sale in your medicine approved ars

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For warnings, the precautions and cons-indications, please see the instructions.

Description

Indications
ADVILTAB 400 mg coated tablet is indicated for the acute treatment of fever and / or pain such as headaches, flu symptoms, toothache, menstrual pain and aches. ADVILTAB 400 mg for adults and children from 11-12 years.

Dosage and route of administration
For adults and children from 11 to 12 years (about 30 kg), 400 mg 1 tablet ADVILTAB repeat if necessary after 6 hours. In all cases, do not exceed 3 tablets per day.

Orally.

Composition
IBUPROFEN 400 MG. EXCIPIENTS: MAIZE STARCH; Pregelatinized starch; Colloidal anhydrous silica; Stearic acid; SUCROSE; STARCH POTATO ACETYL (Perfectamyl GEL 45); POVIDONE; POLYSORBATE 80; MACROGOL 6000; TITANIUM DIOXIDE (E 171); CALCIUM CARBONATE; TALC; CARNAUBA WAX; BLACK INK opacode S-1-17823; (SHELLAC, BLACK IRON OXIDE (E172), N-BUTYL ALCOHOL, Purified water, Propylene Glycol, Isopropyl Alcohol, AMMONIUM HYDROXIDE); FAQs COATED TABLETS 1.

Cons-indications and warnings
Pregnancy more than 5 months; history of allergy or asthma triggered by taking ibuprofen or substances near activity such as other non-steroidal anti-inflammatory drugs, aspirin; liver failure; severe renal impairment; severe heart failure; systemic lupus erythematosus; history of hemorrhage or gastrointestinal perforation; active peptic ulcer; Allergy to fructose.
ADVILTAB 400 mg is a medication that requires special attention for subjects with a history of hypertension and / or heart failure, cases of salt and water retention, hypertension and edema have been reported in association with NSAID therapy. ADVILTAB 400 mg is not recommended for individuals with gastrointestinal problems (ulcers, gastrointestinal perforation).

Packaging
Blister 14 tablets

Warnings on drugs

Warning, the drug is not a product like any other. Read the package leaflet before ordering. Do not leave medicines out of reach of children. If symptoms persist, seek the advice of your doctor or pharmacist. Attention to incompatibilities on products in your.

Tell your pharmacist online treatments underway to identify possible incompatibilities. The checkout form contains a custom message field provided for this purpose.

Click here to find record of the drug at the site of the National Security Agency of Medicines and Health Products.

Pharmacovigilance : Report or a related adverse event (s) (s) (s) the use of a drug

VIDAL OF THE FAMILY

ADVIL 400 mg

Non-steroidal anti-inflammatory drug

ibuprofen

. Presentations . Composition . Indications . Contraindications . Warning . Drug Interactions . Pregnancy and breastfeeding . Directions for use and dosage . Advice . Undesirable effects . Lexicon

PRESENTATIONS (summary)

ADVIL 400 mg: tablet; box of 14.
-

Pfizer Family Health Laboratory

COMPOSITION (summary)
p cp
Ibuprofen 400 mg
Sucrose +

INDICATIONS (summary)
This drug is a non- steroidal anti-inflammatory drug ( NSAID ). It combats pain and lowers the fever. Its anti-inflammatory properties manifest in high doses.
It is used in the treatment of short duration of fever and pain (headaches, dental pain, aches, painful periods ...).
It is also used in the treatment of migraine attack in adults, after at least medical advice.
CONTRAINDICATIONS (summary)
This medication should not be used in the following cases:
WARNING (Contents)
Prolonged treatment or overdosage of NSAIDs may result in serious adverse reactions.
Some situations should lead to further treatment only after medical advice:
  • severe heartburn or black and foul-smelling stools that may indicate irritation or bleeding of the digestive tract;
  • rash without obvious cause;
  • asthma attack ;
  • unusual and intense fatigue, or a sharp and significant decrease in the volume of urine in a person suffering from heart failure , dehydration or diuretic treatment.
Precautions are necessary in the elderly or in case of a history of stomach or duodenal ulcer or haemorrhagic risk, especially digestive ( Crohn 's disease , ulcerative colitis ).
The use of NSAIDs is not recommended in children with varicella: it may increase the risk of infectious, exceptional but potentially serious complications.
NSAIDs have an inhibitory effect on ovulation and are likely to decrease fertility in women. This effect is reversible upon discontinuation of treatment.
Some doctors consider that anti-inflammatories can decrease the effectiveness of intrauterine devices (IUDs) and expose them to an unwanted pregnancy risk. This risk is highly controversial.
Conductor: This medication may be responsible, in rare cases, for dizziness or disturbances of vision.
DRUG INTERACTIONS (summary)
This medication may interact with other medicines, including: Inform your doctor or pharmacist if you are taking a diuretic , an ACE inhibitor , an angiotensin II inhibitor , a beta-blocker, or a medicine containing ciclosporin.
PREGNANCY AND BREAST-FEEDING (summary)
Pregnancy :
Adverse effects to the unborn child have been demonstrated when NSAIDs are used during the last 4 months of pregnancy; the risk exists even with a single intake and even if the pregnancy is over term. The use of this medication is contraindicated during this period.
During the first 5 months, the effect of this medication is poorly understood: only your doctor can evaluate the possible risk of its use in your case.

Breastfeeding:
Ibuprofen is low in breast milk: however, as a precaution, it is not recommended during breast-feeding.
DIRECTIONS FOR USE AND DOSAGE (summary)
In order to limit the occurrence of digestive disorders , this medication can be taken during meals with a large glass of water. However, in the case of acute pain, the fasting catch ensures a faster effect. Catches must be spaced at least 6 hours apart.

Usual dosage:

Pain and fever:
  • Adult and child over 30 kg (about 11 years): 1 tablet with 400 mg, to be renewed if necessary after a minimum delay of 6 hours. Do not exceed 3 tablets per day.
    In the absence of medical advice, the duration of treatment should be limited to 5 days in case of pain and 3 days in case of fever.
Migraine attack:
  • Adult: 1 tablet 400 mg, to be taken at the beginning of the crisis. There is no need to take a tablet if the effect is insufficient. On the other hand, if the symptoms reappear, it is possible to take 1 additional tablet within a minimum delay of 8 hours between the 2 catches.
    Do not exceed 3 days of treatment.
TIPS (summary)
This 400 mg dosage is intended for use when ibuprofen 200 mg is insufficiently effective. It can nevertheless be used from the outset in the treatment of severe pain.
Do not exceed the recommended dosage or duration of treatment recommended by your doctor or pharmacist to limit side effects.
Taking this medication does not dispense with the usual measures to help cede the migraine attack: lie down in a dark room.
This medicinal product may be freely available in certain pharmacies; nevertheless, do not hesitate to ask your pharmacist for advice.
POSSIBLE ADVERSE EFFECTS (summary)
Nausea, vomiting, gastritis .
Rarely:

GLOSSARY (summary)


NSAIDs
Abbreviation for non-steroidal anti-inflammatory drug. Family of anti-inflammatory drugs that are not derived from cortisone (steroids), and the best known of which is aspirin.


allergy
Skin reaction (itching, pimples, swelling) or general discomfort occurring after contact with a particular substance, use of a medication, or ingestion of food. The main forms of allergy are eczema, urticaria, asthma, angioedema and allergic shock (anaphylactic shock). Food allergy can also result in digestive disorders.


anemia
Reduction in the level of hemoglobin in the blood, which usually results in a decrease in the number of red blood cells. Iron is essential for the synthesis of hemoglobin. Iron deficiency during pregnancy, a vegetarian diet, abundant or repeated haemorrhage (menstruation) is a common cause of anemia. Other causes, more rare, are related to vitamin deficiencies of group B.


antecedent
Affection healed or always in evolution. The antecedent may be personal or family. The background is the history of a person's health.


antiplatelet agents
Medication that prevents the platelets from clumping and therefore the clots from forming. The oldest platelet antiaggregant is aspirin taken in small doses.
Anti-aggregants should not be confused with anticoagulants with a different mechanism of action.


anti coagulants
Medication that prevents blood from coagulating and therefore prevents clots from forming in the blood vessels.
Anticoagulants are used to treat or prevent phlebitis, pulmonary embolism, certain infarcts. They also prevent the formation of clots in the heart during rhythm disorders such as atrial fibrillation or in the case of an artificial heart valve.
There are two main types of anticoagulants:
  • oral anticoagulants, which block the action of vitamin K (antivitamin K, or AVK) and whose effectiveness is controlled by a blood test: INR (formerly TP);
  • injectable anticoagulants derived from heparin, the efficacy of which can be controlled by the blood assay of anti-Xa activity, Howell's Time (TH) or Cephalin Kaolin Time (TCK) depending on the products used. A regular dosage of blood platelets is necessary throughout the life of a heparin derivative.


anti-inflammatory
Medicine that fights against inflammation. It can be either derived from cortisone (steroidal anti-inflammatory), or not derived from cortisone (nonsteroidal anti-inflammatory or NSAID).


asthma
Disease characterized by difficulty breathing, often resulting in wheezing. Asthma, permanent or occurring by crisis, is due to a narrowing and inflammation of the bronchi.


beta blockers
Family of drugs used primarily in cardiology. They block the action of adrenaline (and other related hormones) on the heart, vessels and bronchi.


Crohn
inflammation of the intestine, which can cause ulcers and narrowing. It often becomes chronic and can be accompanied by persistent diarrhea and malnutrition.


diuretic
Medication allowing increased kidney water removal. Most often, this loss of water follows the loss of salts caused by the drug (salidiuretic).
Diuretics are mainly used in the treatment of high blood pressure, while their mechanism of action in this disease is poorly understood. They are also prescribed in acute or chronic heart failure, edema and other rarer ailments.
These drugs cause loss of sodium and potassium (except for some of them called "potassium-sparing"). Their prolonged administration therefore requires regular blood potassium control, to avoid heart problems that may result from hypokalemia (lack of potassium in the blood). Lack of sodium is another possible but less frequent consequence of the prolonged use of diuretics; it is also detected by a blood test.


duodenum
A part of the intestine into which food from the stomach penetrates.


skin rash
Appearance of pimples or plaques on the skin. These lesions can be due to a food, a drug, and translate an allergy or a toxic effect. Many viruses can also cause pimple eruptions: rubella, roseola and measles are the most common.


gastritis
Inflammation of the stomach favored by stress, tobacco, alcohol and certain drugs such as aspirin or anti-inflammatory drugs.


hemorrhage
Loss of blood from an artery or vein. Hemorrhage can be external, but also internal and go unnoticed.


angiotensin II inhibitor
These drugs are sometimes called sartans, for the names of the molecules belonging to this family end with sartan (losartan, candesartan, etc.).
This family of drugs blocks the action of angiotensin II, a substance that increases blood pressure and tires the heart.
Angiotensin II inhibitors are used to treat high blood pressure.


ACE inhibitor
This family of drugs blocks the action of an enzyme, which converts angiotensin I (naturally inactive substance) to angiotensin II. This last substance increases blood pressure and fatigue the heart.
ACE inhibitors are used to treat high blood pressure, heart failure or myocardial infarction.


heart failure
Inability of the heart to fulfill its function as a pump. The main symptoms of heart failure are fatigue and shortness of breath during an effort.


Hepatic insufficiency
Inability of the liver to perform its function, which is essentially the elimination of some waste, but also the synthesis of many biological substances essential to the body: albumin, cholesterol and coagulation factors (vitamin K, etc.).


renal failure
Inability of the kidneys to eliminate waste or medicinal substances. Advanced renal insufficiency does not necessarily result in a decrease in the amount of urine excreted. Only a blood test and creatinine dosage may reveal this disease.


lupus erythematosus
Skin disease causing redness of the central part of the face. There are two main forms: discoid lupus (only cutaneous) and disseminated lupus (associated with lesions of the deep organs).


migraine
Special headache usually affecting the right or left half of the head, often associated with a fear of light and noise.


blood count
The count measures the number of red blood cells (red blood cells), white blood cells (leukocytes) and platelets in the blood. The blood formula specifies the percentage of different white blood cells: neutrophils, eosinophils, basophils, lymphocytes, monocytes.
Abbreviation: NFS.


edema
Accumulation of water or lymph causing localized swelling.


dosage
Quantity and distribution of the dose of a drug according to the age, weight and general condition of the patient.


allergic reaction
Reaction due to hypersensitivity of the organism to a drug. Allergic reactions can take a wide variety of aspects: urticaria, angioedema, eczema, eruption of pimples resembling measles, etc. Anaphylactic shock is a generalized allergic reaction that causes discomfort due to a sudden drop in blood pressure.


ulcerative colitis
Inflammatory disease of the rectum and colon, which evolves by flare-ups. Each flare is accompanied by fever, bloody stools.


overdose
Excessive intake of a drug may result in an increase in the intensity of adverse effects or even in the development of specific adverse effects.
This overdose may result from accidental or voluntary poisoning for suicide, so consult your local Poison Control Center (listed in the appendix to the book). However, in most cases, overdose is the result of an error in the understanding of the prescription, or the search for an increase in efficacy by exceeding the recommended dosage. Finally, untimely self-medication may lead to excessive absorption of the same substance contained in different drugs. Some drugs are particularly prone to this risk because they are (wrongly) considered to be harmless: vitamins A and D, aspirin, etc. Stopping or decreasing drug intake helps to remove the disorders associated with an overdose.


crisis management
As opposed to long-term treatment, short-term and episodic treatment in the context of seizure or outbreak diseases.


transaminases
Enzymes dosed in the blood, which rate rises during some hepatitis. They are included in blood tests as SGOT and SGPT or ASAT and ALAT.


digestive disorders
Set of symptoms indicating irritation or malfunction of the digestive tract. One or more disorders may be present: nausea, vomiting, aerophagia, abdominal pain, heartburn, bloating, flatulence, diarrhea or constipation, etc. Antibiotics can promote candidiasis, often responsible for digestive disorders.


ulcer
Injury of skin, mucous membranes or cornea.
  • Leg ulcer: chronic wound due to poor circulation of blood.
  • Gastroduodenal ulcer: a localized wound in the mucosa of the stomach or duodenum due to excess acidity and very often to the presence of a bacterium (Helicobacter pylori). The ulcer is favored by stress, alcohol, smoking and certain medications (aspirin, NSAIDs, etc.).


dizziness
Symptom that can mean an impression of loss of balance (common sense) or, more strictly, a sense of rotation on oneself or the environment (medical sense).

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Pharmacovigilance : Déclarer un ou des effet(s) indésirable(s) lié(s) à l'utilisation d'un médicament

NOTICE

ANSM - Last updated: 17/08/2017

Name of the medicinal product

ADVIL 400mg, coated tablet

Ibuprofen

framed

Please read this leaflet carefully before you start taking this medicine because it contains important information for you.

You should always take this medication exactly as prescribed in this leaflet or by your doctor or pharmacist.

· Keep this leaflet. You might need to read it again.

· Ask your pharmacist for advice or information.

· If you experience any side effects, talk to your doctor or pharmacist. This also applies to any side effects not mentioned in this leaflet. See section 4.

· You should contact your doctor if you do not feel better or feel less well: - after 3 days in the adolescent, - after 3 days in case of fever or migraine and 5 days in case of pain in the 'adult.

What is in this leaflet?

1. What is ADVIL 400mg, coated tablet and in which cases it is used?

2. What information should I take before taking ADVIL 400mg, coated tablet?

3. How to take ADVIL 400mg, coated tablet?

4. What are the possible side effects?

5. How to store ADVIL 400mg, coated tablet?

6. Package contents and other information.

1. WHAT IS ADVIL 400mg, coated tablet AND WHAT CASES IS IT USED FOR?

Pharmacotherapeutic group - ATC code: N02B

OTHER ANALGESIC AND ANTIPYRETIC

This medicine contains a non-steroidal anti-inflammatory drug: ibuprofen.

It is indicated in adults and children from 30 kg (approximately 11-12 years), in the short-term treatment of fever and / or pain such as headache, flu-like conditions, dental pain , aches and pains.

It is indicated in adults , after at least medical advice , in the treatment of mild to moderate migraine attack, with or without aura.

2. BEFORE YOU TAKE ADVIL 400mg, coated tablet?

If your doctor has told you about an intolerance to some sugars, contact your doctor before taking this medicine

Do not take ADVIL 400mg, coated tablet:

· if you are allergic to ibuprofen or to any of the other ingredients of this medication mentioned in section 6.

· after 5 months of pregnancy (24 weeks of amenorrhea),

· if you have a history of allergy or asthma triggered by taking this medication or a related drug, including other non-steroidal anti-inflammatory drugs, acetylsalicylic acid (aspirin),

· if you have a history of gastrointestinal bleeding or ulcers associated with previous NSAID treatments,

· if you have an ulcer or bleeding from the stomach or bowel in progress or recurring,

· if you have gastrointestinal bleeding or history of gastrointestinal hemorrhage, cerebral hemorrhage or other ongoing bleeding,

· if you have severe liver disease,

· if you have a serious kidney disease,

· if you have a serious heart disease,

· if you have systemic lupus erythematosus,

IN CASE OF DOUBT, IT IS ESSENTIAL TO ASK FOR THE OPINION OF YOUR DOCTOR OR YOUR PHARMACIST.

Warnings and Precautions

Take special care with ADVIL 400mg, coated tablet:

In high doses, greater than 1200 mg / day, this drug has anti-inflammatory properties and can cause serious disadvantages that are observed with non-steroidal anti-inflammatory drugs.

Drugs such as ADVIL 400mg, coated tablet may increase the risk of heart attack ("myocardial infarction") or stroke. The higher the dose, the greater the risk.

Do not exceed recommended dosage or treatment time.

If you have heart problems including heart failure, angina pectoris (chest pain) or if you have had a heart attack, bypass surgery, lower limb arterial disease (poor circulation due to shrinkage or obstruction arteries), or any type of stroke (including a minor stroke or transient ischemic stroke "TIA") or if you have risk factors for this type of disease (eg high blood pressure, diabetes , high cholesterol, family history of heart disease or stroke or if you smoke), talk to your doctor or pharmacist before taking Advil 400 mg.

Special warnings

If you are a woman, ADVIL 400mg, coated tablet can alter your fertility. Its use is not recommended in women who wish to conceive a child. For women who have reproductive difficulties or who are undergoing reproductive function tests, please tell your doctor or pharmacist before taking ADVIL 400mg, coated tablet.

When administered to the elderly, this drug should be used with caution.

Elderly patients have a higher risk of adverse effects, particularly for gastrointestinal haemorrhage, ulcers and perforations. Renal, hepatic and cardiac functions should be closely monitored. The dosage should be as low as possible for the shortest time needed to relieve symptoms.

The use of this medication is not recommended in patients with fructose intolerance, glucose-galactose malabsorption syndrome or sucrase / isomaltase deficiency (rare hereditary diseases).

BEFORE YOU USE THIS MEDICINE, CONSULT YOUR DOCTOR IN CASE:

· a history of asthma associated with chronic rhinitis, chronic sinusitis or polyps in the nose. The administration of this specialty can lead to an asthma attack, especially in some people allergic to acetylsalicylic acid (aspirin) or a non-steroidal anti-inflammatory ( see section "Do not take ADVIL 400mg, coated tablet in cases below " ),

· coagulation disorders, and anticoagulant therapy. This medication may cause severe gastrointestinal symptoms,

· digestive antecedents (hiatal hernia, digestive hemorrhage, old stomach or duodenal ulcer),

· heart disease, liver (including cirrhosis of the liver) or kidney,

· of varicella. This medication is not recommended because of exceptional severe infections of the skin,

· concomitant treatment with other drugs that increase the risk of peptic ulcer or haemorrhage, eg, oral corticosteroids, antidepressants (SSRIs, ie, Selective Serotonin Recapture Inhibitors), medicines preventing the formation of blood clots such as aspirin or anticoagulants such as warfarin. If you are in any of these conditions, consult your doctor before taking ADVIL 400mg, coated tablet ( see section "Take or use other medicines" ),

· of non-steroidal anti-inflammatory therapy (NSAID)

· concomitant therapy with methotrexate at doses greater than 20 mg per week or with pemetrexed ( see section "Taking or using other medicinal products" ).

· Dehydrated children and adolescents have a risk of kidney failure. Ask your doctor for advice before using ADVIL 400 mg if the teen has not been drinking liquid or has lost fluid due to continuous vomiting or diarrhea .

DURING TREATMENT, IN CASE OF:

· of vision problems, PREVENT YOUR DOCTOR,

· gastrointestinal haemorrhage (discharge from the mouth or stool, blood in vomiting, stool coloration in black), STOP TREATMENT AND IMMEDIATELY CONTACT MEDICAL OR EMERGENCY MEDICAL SERVICE,

· onset of severe allergic reaction: redness of the skin, rash, STOP TREATMENT AND IMMEDIATELY CONTACT MEDICAL OR EMERGENCY MEDICAL SERVICE,

· of appearances of cutaneous or mucosal signs that resemble a burn (redness with bubbles or blisters, ulcerations), STOP THE TREATMENT AND CONTACT IMMEDIATELY A DOCTOR OR AN EMERGENCY MEDICAL SERVICE,

· of allergy-related signs including asthma attack or sudden swelling of the face and neck ( see section "What are the possible side effects?" ), STOP TREATMENT AND CONTACT IMMEDIATELY A DOCTOR OR A MEDICAL SERVICE EMERGENCY.

This medicine contains a non-steroidal anti-inflammatory drug: ibuprofen.

You should not take other medicines containing non-steroidal anti-inflammatory drugs (including selective cyclooxygenase 2 inhibitors) and / or acetylsalicylic acid (aspirin) at the same time as this medication.

Read the leaflets carefully for other medicines you are taking to ensure that there are no nonsteroidal anti-inflammatory drugs and / or acetylsalicylic acid (aspirin).

Talk to your doctor or pharmacist before taking ADVIL 400mg, coated tablet .

Children and Youth

Not applicable.

Other medicines and ADVIL 400mg, coated tablet

Inform your doctor or pharmacist if you are taking, have recently taken or may take any other medicines.

Always tell your doctor, dentist or pharmacist if you are taking any of the following medications in addition to ADVIL 400mg, coated tablet:

· aspirin (acetylsalicylic acid) or other non-steroidal anti-inflammatory drugs

· corticosteroids

· anticoagulant drugs (such as anticoagulants / antiplatelet agents such as aspirin (acetylsalicylic acid), warfarin, ticlopidine, injectable heparin.

· lithium

· methotrexate

· Medicines that reduce blood pressure (angiotensin-converting enzyme inhibitors, such as that captopril, diuretics, beta-blockers such as drugs containing atenolol and angiotensin II antagonists such as losartan)

· some antidepressants (selective serotonin reuptake inhibitors (increased risk of digestive hemorrhage))

· pemetrexed

· ciclosporin, tacrolimus.

· Tenofovir disoproxil

ADVIL 400mg, tablet coated with food and beverages

Not applicable.

Pregnancy and breast feeding

If you are pregnant or breastfeeding, think you may be pregnant or plan a pregnancy, ask your doctor for advice or pharmacist before taking this medication.

Pregnancy

During the first trimester of pregnancy (12 weeks of amenorrhoea, 12 weeks after the first day of your last menstrual period), your doctor may prescribe this medication if necessary.

For 2.5 to 5 months of pregnancy (12 to 24 weeks of amenorrhea), this medication will only be used on the advice of your doctor and in brief dosage. Prolonged use of this medication is strongly discouraged.

After 5 months of pregnancy (beyond 24 weeks of amenorrhea), you should NOT take this medication because its effects on your child can have serious consequences, especially on a cardiopulmonary level and renal, even with a single dose.

If you are taking this medication when you are more than five months pregnant, please speak to your obstetrician gynecologist for appropriate monitoring.

feeding

This drug passes into breast milk. As a precaution, it should be avoided during breastfeeding

Driving and using machines

In rare cases, taking this medicine may cause dizziness and blurred vision

ADVIL 400mg, coated tablet contains sucrose

3. HOW TO TAKE ADVIL 400mg, coated tablet?

Always take this medication exactly as prescribed by your doctor or pharmacist. Check with your doctor or pharmacist if in doubt.

The occurrence of adverse reactions can be minimized by using the lowest possible dose for the shortest duration necessary to alleviate the symptoms.

Dosage

Painful and / or febrile conditions

ADULTS TO ADULT AND CHILD WEIGHT MORE THAN 30 KG (11-12 years).

The usual dosage is 1 tablet with 400 mg per dose, to be renewed if necessary every 6 to 8 hours, without exceeding 3 tablets to 400 mg per day (ie 1200 mg per day).

The tablet dosed at 400 mg is reserved for pain or fever more intense or not relieved by a tablet dosed with 200 mg of ibuprofen.

The elderly with an increased risk of adverse effects should use the lowest possible dose for the shortest time necessary to relieve symptoms.

Do not exceed the recommended doses or the duration of treatment (3 days in case of fever, 5 days in case of pain).

The maximum dose is 3 tablets per day (1200 mg).

In the event of a migraine attack

RESERVED FOR ADULTS

1 tablet at 400 mg as soon as possible from the onset of the crisis.

If a patient is not relieved after the first dose, a second dose should not be taken during the same course. However the crisis can be treated with another treatment that is not a nonsteroidal anti-inflammatory or aspirin.

If the pain reappears a second dose can be taken as long as it meets an 8 hour interval between the 2 doses.

If in doubt, ask your doctor or pharmacist for advice.

Administration mode

Oral use.

Swallow the tablet without chewing it with a large glass of water.

The tablets should be taken preferably during a meal

Frequency of Administration

Systematic catches help to avoid oscillations of pain or fever.

They should be spaced at least 6 hours.

Duration of treatment

In adolescents, if this medication is needed for more than 3 days, or if the symptoms worsen, it is advisable to consult your doctor.

In adults, the duration of use is limited to:

· 3 days in case of fever,

· 3 days in case of migraine

· 5 days in case of pain.

In adults, if the pain persists more than 5 days or the fever more than 3 days, or if they worsen or if a new disorder occurs, inform your doctor.

In case of a migraine attack the duration of treatment should not exceed 3 days.

If symptoms persist or if new symptoms appear, seek the advice of your pharmacist or doctor.

If you feel that the effect of ADVIL 400 mg, coated tablet is too strong or too weak, talk to your doctor or pharmacist.

If you take more ADVIL 400mg, coated tablet than you should

In case of accidental overdose or poisoning, STOP TREATMENT AND QUICKLY CONSULT A DOCTOR OR AN EMERGENCY MEDICAL SERVICE.

Symptoms of overdose include: dizziness, abdominal pain, nausea, vomiting, dizziness, drowsiness, headache, convulsions, loss of consciousness, difficulty breathing ("dyspnea" ), respiratory depression, abnormal blood pressure decline ("hypotension"), renal insufficiency, abnormally high blood acidity ("metabolic acidosis"), abnormal increase in blood potassium ("hyperkalaemia"), abnormal blood liver function.

If you forget to take ADVIL 400mg, coated tablet

Do not take a double dose to make up for a missed dose.

If you stop taking ADVIL 400mg, coated tablet

Not applicable.

If you have any further questions on the use of this medication, ask your doctor or pharmacist.

4. WHAT ARE POSSIBLE SIDE EFFECTS?

Like all medicines, this medicine may cause side effects, although not everybody gets them.

Drugs such as ADVIL 400mg, coated tablet may increase the risk of heart attack (myocardial infarction), angina pectoris or stroke.

May cause allergic reactions:

· (rash, maculopapular rash, erythema multiforme, purpura), itching ("pruritus"), edema, aggravation of chronic urticaria, edema of the face

· respiratory distress, asthma attack, respiratory discomfort ("bronchospasm"), wheezing or difficult breathing ("dyspnea"),

· general: sudden swelling of the face and neck with respiratory discomfort (angioedema), anaphylactic reaction, hypersensitivity reaction.

In rare cases, bleeding, gastrointestinal perforation or digestive ulceration (abdominal pain, high abdominal pain, blood rejection by the mouth ("hematemesis") or stools, stool coloration ("melaena"), exacerbation of inflammation of the intestine ("colitis") or Crohn's disease (see section "Take special precautions with ADVIL 400mg, coated tablet"). These are all the more frequent because the dosage used is high.

Exceptionally, headaches accompanied by nausea, vomiting and neck stiffness can be observed: symptoms of meningitis.

Exceptionally, severe skin infections have been observed in cases of chicken pox.

Extremely bubbling of the skin or mucous membranes (burning sensation accompanied by redness with bubbles, blisters, ulcers ("Lyell Syndrome" and "Stevens-Johnson Syndrome") may occur.

In all these cases, you should stop treatment immediately and notify your doctor .

During treatment, there may be:

· stomach upset, vomiting, nausea, diarrhea, constipation, flatulence, difficult digestion ("dyspepsia"), abdominal distension, gastritis,

· dizziness, dizziness, headache, rare visual disturbances, significant decrease in urine, abnormal blood in the urine ("hematuria") and protein in the urine ("proteinuria"), kidney failure and other conditions kidney disease ("interstitial nephritis", "nephrotic syndrome", "papillary necrosis").

In all these cases, you should tell your doctor .

Exceptionally, changes have been observed in the liver function or blood count (abnormal decrease in blood cell count: white cells ("agranulocytosis", "leukopenia") or red blood cells ("anemia", "aplastic anemia" "Hemolytic anemia", decreased hematocrit and hemoglobin) or platelets ("thrombocytopenia") may be severe.

Other very rare adverse reactions:

· Nervousness, ringing of ears,

· Oral ulcers,

· Abnormally high blood pressure ("hypertension"),

· Heart failure,

· Liver problems: symptoms may include yellowing of the skin and white of the eyes ("jaundice"), hepatitis,

· Peripheral edema, swelling.

Declaration of side effects

If you notice any side effects, talk to your doctor or pharmacist. This also applies to any side effects not listed in this leaflet. You can also report adverse reactions directly via the national reporting system: National Agency for the Safety of Medicines and Health Products (ANSM) and network of Regional Centers of Pharmacovigilance - Website: www.ansm.sante.fr

By reporting adverse reactions, you are helping to provide more information about the safety of the drug.

5. HOW TO STORE ADVIL 400mg, coated tablet?

Keep this medicine out of the reach and sight of children.

Do not use this medicine after the expiry date which is stated on the package. The expiry date refers to the last day of that month.

No special storage conditions.

Do not throw any medicines into drains or rubbish. Ask your pharmacist to remove any medications you are no longer using. These measures will help protect the environment.

6. PACKAGE CONTENTS AND OTHER INFORMATION

What ADVIL 400mg contains, coated tablet

· The active substance is:

Ibuprofen................................................. .................................................. .................. 400mg

For a coated tablet

· The other components are:

Core : corn starch, pregelatinized starch, anhydrous colloidal silica, stearic acid. Coating : Sucrose, oxidized potato starch (perfectamyl 45), polysorbate 80, macrogol 6000, povidone, red iron oxide (E172), titanium dioxide (E171), calcium carbonate, talc, carnauba wax, black ink Opacode S-1-17823 (shellac, black iron oxide (E172), N-butyl alcohol, purified water, propylene glycol, isopropyl alcohol, ammonium hydroxide).

What is ADVIL 400mg, coated tablet and contents of the pack

Aspect of ADVIL 400mg and contents of the pack

This medication is in the form of a coated tablet. Box of 10 or 14 tablets.

Not all pack sizes may be marketed.

Marketing Authorization Holder

PFIZER FAMILY HEALTH

23-25, AVENUE OF DOCTOR LANNELONGUE

75014 PARIS

Marketing Authorization Operator

PFIZER FAMILY HEALTH

23-25, AVENUE OF DOCTOR LANNELONGUE

75014 PARIS

Maker

PFIZER CONSUMER MANUFACTURING ITALY SRL

VIA NETTUNENSE, 90

04011 APRILIA - LT

ITALY

Names of the medicinal product in the Member States of the European Economic Area

Not applicable.

The last date on which this leaflet was revised is:

[to be completed later by the holder]

<{MM / YYYY}> <{YYYY month}.>

Other

Detailed information on this medicine is available on the ANSM website (France).

Health Education Council:

"WHAT TO DO IN THE EVENT OF FEVER":

The normal temperature of the body is variable from one individual to another and between 36.5 ° C and 37.5 ° C.

An increase of more than 0.8 ° C is considered a fever.

In adults and children over 30 kg (approximately 11-12 years of age): If the condition is too troublesome, you can take a medicine containing ibuprofen at the indicated dosage.

With this medication, the fever should drop rapidly. Nevertheless :

· if other signs appear (such as a rash),

· if the fever persists for more than 3 days or if it worsens,

· if the headache becomes violent, or in case of vomiting,

CONSULT YOUR DOCTOR IMMEDIATELY.

"WHAT TO DO IN CASE OF PAIN":

· In the absence of improvement after 5 days of treatment,

· If the pain returns regularly,

· If accompanied by fever,

· If she wakes you up at night,

CONSULT YOUR DOCTOR IMMEDIATELY.

MIGRAINE OR HEADSELF?

· Headache for a few hours to 3 days (without pain between seizures).

· At least 5 crises in your life

· Headache having at least 2 of the following characteristics:

o Located on one side of the head;

o Pulsatile (taps in the head);

o Intensity of moderate or severe pain;

o Pain aggravated by physical activities (climbing or descending stairs for example).

· The headache is accompanied by at least one of the following signs:

o nausea and / or vomiting;

o discomfort to light (photophobia) and / or noise (phonophobia).

A positive answer to 3 or 4 of these questions means that you are probably or certainly migraineous.

IS YOUR TREATMENT EFFECTIVE?

· Are you relieved significantly 2 hours after taking?

· Is this drug well tolerated?

· Do you use a single medication intake?

· If you are taking this medication, you may resume your usual activities 2 hours after taking it.

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